In 1987, Guns N' Roses released its debut album, Appetite for Destruction, which to date has sold over 28 million copies worldwide, despite containing only eight tracks, four of which were included on the previously released EP Live ?! In 1990, Steven Adler was fired from the band because of his heroin addiction; he was replaced by Matt Sorum of The Cult. In 1993, the band released "The Spaghetti Incident?In May 1991, Guns N' Roses embarked on the two-and-a-half-year-long Use Your Illusion Tour. ", a cover album of mostly punk songs, which proved less successful than its predecessors.The band played a brief tour of Europe and North America, before disbanding in 1997.

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Both Squires and Rouse joined after the recording of the band's debut album, Dark Days, released in 2001.

Dave Dederer, formerly of The Presidents of the United States of America, took up recording duties for the album.

Loaded independently released the live record Episode 1999: Live, before disbanding in late 1999.

In 2000, Mc Kagan reformed Loaded, remaining as the lead vocalist but switching from bass to rhythm guitar, and adding drummer Geoff Reading of Green Apple Quick Step, guitarist Mike Squires of Harvey Danger, and bassist Jeff Rouse of Alien Crime Syndicate.

Mc Kagan rejoined the band in 2016, following their induction into the Rock and Roll Hall of Fame.

Towards the end of his first tenure with Guns N' Roses, Mc Kagan released a solo album, Believe in Me (1993), and formed the short-lived supergroup Neurotic Outsiders.and subsequently lost all commercial rights to release the record.For the tour supporting his ill-fated solo album, he formed the band Loaded, which consisted of Mc Kagan on bass and vocals, Dez Cadena, formerly of Black Flag, on guitar, Michael Barragan, formerly of Plexi, on guitar, and Taz Bentley, formerly of The Reverend Horton Heat, on drums.Following his departure from Guns N' Roses in 1997, Mc Kagan briefly reunited with his pre-success Seattle punk band 10 Minute Warning, before forming the still-active hard rock band Loaded, in which he performs lead vocals and rhythm guitar.Between 20, he played bass in the supergroup Velvet Revolver with his former Guns N' Roses bandmates Slash and Matt Sorum.In 1995, with Guns N' Roses largely inactive, Mc Kagan formed the supergroup Neurotic Outsiders with Steve Jones of the Sex Pistols, John Taylor of Duran Duran, and his Guns N' Roses bandmate Matt Sorum.